The Minipig in Biomedical Research (2011, Hardcover) by download book FB2, PDF, DOC

9781439811184
English

1439811180
The Minipig in Biomedical Researchis a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors " global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig "s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes How to " and Why " and "What to expect in the normal ", combining enthusiasm and experience with critical assessment of its values and potential problems., The first comprehensive single-source reference on the minipig, this accessible manual provides a resource for research scientists on the potential and use of the minipig as a model. Written by acknowledged experts in the field, and drawing on the authors " global contacts and experience with regulatory authorities and the pharmaceutical industry, this book exposes new information to the public domain such as novel procedures and regulatory aspects. It includes basic information, experimental techniques, animal welfare issues, pharmacology, toxicology, immunology, disease models, and new horizons and perspectives.

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